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Diagnostics and prognostics in rotating machinery is a subject of much on-going research. There are three approaches to diagnostics and prognostics. These include experience-based approaches, data-driven techniques and model-based techniques. Bayesian data-driven techniques are gaining widespread application in diagnostics and prognostics of mechanical and allied systems including slow rotating bearings, as a result of their ability to handle the stochastic nature of the measured data well. The aim of the study is to detect incipient damage of slow rotating bearings and develop diagnostics which will be robust under changing operating conditions. Further it is required to explore and develop an optimal prognostic model for the prediction of remaining useful life (RUL) of slow rotating bearings. This research develops a novel integrated nonlinear method for the effective feature extraction from acoustic emission (AE) signals and the construction of a degradation assessment index (DAI), which is subsequently used for the fault diagnostics of slow rotating bearings. A slow rotating bearing test rig was developed to measure AE data under variable operational conditions. The proposed novel DAI obtained by the integration of the PKPCA (polynomial kernel principal component analysis), a Gaussian mixture model (GMM) and an exponentially weighted moving average (EWMA) is shown to be effective and suitable for monitoring the degradation of slow rotating bearings and is robust under variable operating conditions. Furthermore, this study integrates the novel DAI into alternative Bayesian methods for the prediction of RUL. The DAI is used as input in several Bayesian regression models such as the